The Human Genome Project, completed ten years ago, widely opened the door for the field of Epigenetics as a new CoQ10 venue to study the causes of human disease and to search for predictive biomarkers and therapeutic targets for a wide range of disorders.The field of behavioral and psychiatric epigenetics is still very young, but increasing evidenc
A national evaluation analysis and expert interview study of real-world data sources for research and healthcare decision-making
Abstract Real-world data (RWD) can provide intel (real-world evidence, RWE) for research and development, as well as policy and regulatory decision-making along the full spectrum of health care.Despite calls from global regulators for international collaborations to integrate RWE into regulatory decision-making and to bridge knowledge gaps, some ch
Replication and mediation of the association between the metabolome and clinical markers of metabolic health in an adolescent cohort study
Abstract Metabolomics-derived metabolites (henceforth metabolites) may mediate the relationship between modifiable risk factors and clinical biomarkers of metabolic health (henceforth clinical biomarkers).We set out to study the associations of metabolites with clinical biomarkers and a potential mediation effect in a population of young adults.Fir